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SHMT is present in plant and mammals and plays a crucial part in two major metabolic pathways: 1C metabolism and amino acid metabolism

Preliminary correlations of clinical outcome with in vitro chemosensitivity of second passage human breast cancer cells

Although one must be cautious in extrapolating findings from preclinical animal models to the human condition, there is evidence that chronic stress-induced inhibition of ETC complexes in the inner membrane of mitochondria is a contributing factor in the pathophysiology of depression

Jamalpoor A, van Gelder CA, Yousef Yengej FA, Zaal EA, Berlingerio SP, Veys KR, Pou Casellas C, Voskuil K, Essa K, Ammerlaan CM, Rega LR, van der Welle RE, Lilien MR, Rookmaaker MB, Clevers H, Klumperman J, Levtchenko E, Berkers CR, Verhaar MC, Altelaar M, Masereeuw R, Janssen MJ (2021) Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis

These immunotherapeutic strategies demonstrate significant efficacy in the Panc02 pancreatic cancer model (208, 209)